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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T6113 | ICG-001 | Apoptosis , Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG-001 antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coactivator p300. | |||
T2237 | ICG001 | Epigenetic Reader Domain , Wnt/beta-catenin | |
ICG001 (PRI-724 isomer) antagonizes Wnt/β-catenin/TCF-mediated transcription and specifically binds to element-binding protein (CREB)-binding protein (CBP) with IC50 of 3 μM, but is not the related transcriptional coacti... | |||
T64414 | PRI-724 | C-82 prodrug,Foscenvivint | Wnt/beta-catenin |
PRI-724 (C-82 prodrug) is a selective small-molecule inhibitor of β-catenin/CBP interaction. | |||
T65994 | (6S)-N-Benzyl-6-(4-hydroxybenzyl)-8-(naphthalen-1-ylmethyl)-4,7-dioxohexahydro-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide | ||
Wnt signaling is required for direct multiple biological processes and also plays key roles in the pathogenesis of various diseases. Cyclic AMP response element-binding protein (CREB) is a transcription factor that is a ... |